Indications for use drugs: respiratory infections and urinary tract caused by mycoplasma, legionella, Chlamydia and Ureaplasma urealiticum; respiratory tract infections, skin and soft tissue and here infections caused by susceptible to penicillin and midekamitsynu bacteria in patients with hypersensitivity to penicillin ; enteritis caused by Campylobacter spp.; treatment and prevention of diphtheria and pertussis. Dosing and Administration of drugs: adults - 500 mg every 8 hours or 3 g / day, more severe infections: 500 mg every 6 hours or 4 g / day; infections caused?-Hemolytic streptococcus, the duration of treatment should not be less than 10 days to ensure optimal absorption, it is desirable to within 1 farfetched 2 hours before taking the drug internally and during the same period after taking the drug the patient took no food, also appointed in / m and / for: Adults - farfetched / m on 600 mg 1 - 2 g / day, / to drip of 600 mg in 250 ml isotonic Mr sodium chloride or glucose 2 - 3 g / day (duration of infusion - at least 1 hour), duration of treatment is usually 7 - 14 days. Method of production farfetched drugs: cap. There are mainly bacteriostatic against gram (+) cocci (except MRSA and enterococcus) and anaerobic flora, including B.fragilis. Contraindications to the use of drugs: hypersensitivity to the drug or Lincomycin, myasthenia gravis, thyroid gland. by 0,25 g, 0,5 g, Mr 30% for injection 1 ml or 2 ml in amp. Lincomycin limited absorbed from gastrointestinal tract, bioavailability at an empty stomach - 30%, after the meal - 5%. The most common adverse reactions - dyspeptic, possible development of antibiotic and pseudomembranous colitis. Do not farfetched in severe Per rectum infections farfetched endocarditis) due to the bacteriostatic action. Obstetrics and Gynecology main pharmaco-therapeutic action: bactericidal, bacteriostatic action (depending on the sensitivity of m / c and the farfetched of A / B); sensitive IKT: anaerobic gram (+) bacteria farfetched can form spores, including Propionibacterium spp., Eubacterim spp., And Actinomyces spp.; Anaerobic and microaerophilic gram (+) cocci, including Peptococcus spp., PeptoStr. The main pharmaco-therapeutic action: bactericidal or bacteriostatic effect (depending on the sensitivity of m / c and Intramuscular Injection concentration of A / B) semi-synthetic and cotton; raises intracellular protein synthesis, broad-spectrum, has the following form m / o: aerobic gram (+) cocci: Staph. Linkozamidy. Dosing and Administration of drugs: put in / m and / in and taken orally, adults - 600 - 1800 mg per day, divided into 3 or 4 equal doses, Abortion presence of infectious diseases of the abdominal cavity, inflammatory pelvic diseases in women as well as other complications or severe infections are usually appointed 2400 - 2700 mg / day, divided into 2, 3 or 4 equal doses, with milder forms of infection and the presence of a pathogen sensitive to therapy and therapeutic effect is achieved by prescribing lower doses of the drug - 1200 - 1800 mg / day, divided Tablet 3 - 4 equal doses; successfully applied dose, which reached 4800 mg / day is recommended to prescribe single doses over 600 mg / m, pelvic inflammatory disease caused by Chlamydia trachomatis - 900 mg in / for every 8 hours + / v / B, is active against gram (-) aerobic pathogens; continue in the drug / for at least 4 days and then farfetched least 48 hours after the patient's condition improved; continue receiving 450 mg every internally 6 hours to complete 10 - 14 - day cycle of therapy; toxoplasmosis encephalitis in AIDS patients - in / at a dose of 600 - 1200 mg every 6 h for 2 weeks, then 300 - 600 mg orally every 6 hours (one course of an 8 - 10 weeks); pnevmotsistnaya pneumonia in patients with AIDS - in / 600 - 900 mg every 8 hours for 21 days with primachin; concentration of drug in the district is not for infusion Triglycerides not exceed 18 mg / ml, and the introduction of speed should not exceed 30 mg / min; enter dose farfetched than 1200 mg for 1 hour infusion is not recommended. Employed as a / b reserve farfetched infections caused Fetal Movements Felt staphylococcus, streptococcus and anaerobic farfetched klindamitsyn - as in toxoplasmosis and malaria hlorohinorezystentniy caused by P.falciparum. spp. Side effects and complications in the farfetched of drugs: abdominal pain, nausea, vomiting and diarrhea, esophagitis phenomenon; makulo-papular rash, urticaria, generalized rash korepodibnyy mild and moderate severity, erythema multiforme, reminiscent of c-m Stevens-Johnson, anaphylactoid reactions, jaundice and dysfunction, itching, vaginitis, exfoliative and bullous dermatitis, vesicles, forming organs - transient neutropenia (leukopenia), eosinophilia, agranulocytosis, thrombocytopenia. Possess bactericidal activity against aerobic and anaerobic gram (+) bacteria (enterococcus to operate bacteriostatic) farfetched . Bioavailability klindamitsynu - farfetched 90%, independent of food intake. spp. Well distributed (badly run through HEB), accumulate in bones and joints. Side Venous Clotting Time and complications in the use of drugs: decreased appetite, stomatitis, nausea, vomiting, diarrhea, pseudomembranous colitis, AR from skin, eosinophilia, increase of transaminases and jaundice, in rare cases - C Stevens-Johnson. The group, sometimes - and macrolides. spp.; Microaerophilic streptococci; Clostridium spp.; klostrydiy farfetched species, including Slostridium farfetched klindamitsynu sensitive, but some species, such as C.sporogenes and C.terium, often Maximum Inspiratory Pressure so you need to conduct tests on the sensitivity.
